A Prospective Study Of The Hearing Loss In Global Developmental Delay Children

Background: Developmental disabilities are a group of related chronic disorders of early onset estimated to affect 5–10% ofchildren. Global developmental delay is a subset of developmental disabilities defined as a significant delay in two or more of thefollowing developmental domains: Gross/fine motor, speech/language, cognition, social/personal, and activities of daily living.Aim of the Study: The aim of this study was to describe the clinical profile and audiological profile in children with globaldevelopmental delay presenting to the pediatric ENT unit.Materials and Methods: The study sample size was a total of 121 children with global developmental delay. Children withcomplaints of global developmental delay underwent a detailed ENT examination including examination under microscope ofear which is the standard of care. Hearing loss was assessed by audiological tests such as behavioral observation audiometry(BOA), otoacoustic emission, brain stem evoked response audiometry (BERA), and tympanometry (Tymps). The degree ofhearing loss was classified using the American Speech-Language-Hearing Association classification.Observations and Results: Among 121 children with global developmental delay, there were 72 (59.5%) males. The meanage of the study group was 3.2 years. The youngest child in the study was 6 months old and the oldest child being 14 yearsold. 25 (20.6%) children participating in the study had syndromic association. Of 121 children, only 36 (29%) presented withspeech delay and suspected hearing loss. BOA done in 242 ears showed 56 (23%) ears with normal hearing, 68 (28%) withhearing loss, and inconsistent report in 38 (15.5%) ears. In the 80 remaining ears (33%), test could not be done.Conclusions: The mean age of referral was 3.2 years in global developmental delay children who were referred for theevaluation of speech delay. Among the 121 global developmental delay children included in the study, 36 (29%) had hearingloss with speech delay. Our study detected a higher incidence of undetected hearing loss of 144 ears (59.5%) in children withglobal developmental delay

Isoniazid-induced cerebellitis: a disguised presentation

Cerebellitis is a rarely encountered complication of isoniazid therapy. Its occurrence is usually associated with concomitant renal disease and haemodialysis. Herein, we report the case of a patient with this complication who presented with isolated bilateral symmetrical dentate nucleus T2 hyperintensities on magnetic resonance imaging. Isoniazid neurotoxicity has never been reported to cause bilateral dentate hyperintensities, for which the differentials are few and include metronidazole toxicity.

Postpartum eclampsia without pre-eclamptic prodroma - Case report and literature review

Late postparturn eclampsia without prior pre-eclampsia is known to occur more than 48 hours up to 28 days postpartum. Common preceding symptoms are headache and visual disturbance. Diagnosis is by findings of hypertension, proteinuria, oedema, hyperreflexia +/- hyperuricemia. Magnetic resonance imaging of brain reveals characteristic posterior leukoencephalopathy. Magnesium sulphate is the mainstay of therapy. Three such cases of this rare clinical entity occurring consecutively in a six month period at our hospital are reported. Prolonged postpartum vigilance for blood pressure and neurological symptoms allows timely management and reduction of maternal morbidity and mortality

Lipoprotein(a) as a risk factor for diabetic retinopathy in patients with type 2 diabetes mellitus.

AIMS: To estimate serum lipoprotein(a) [Lp(a)] levels in patients with type 2 diabetes mellitus with and without diabetic retinopathy and to determine the correlation, if any, between serum Lp(a) levels and severity of diabetic retinopathy. MATERIALS AND METHODS: The study included a total of 200 patients of type 2 diabetes mellitus out of which 100 patients who had no retinopathy served as the control group and 100 patients with diabetic retinopathy formed the study group. A detailed fundus examination was done with dilated pupil. The Lp(a) levels were measured quantitatively in fasting venous samples by an immunoturbidimetric method using commercially available kits (Clonital). STATISTICAL ANALYSIS USED: Group comparisons involving qualitative measures were carried out using Chi square test. ANOVA procedure was applied for comparing group means. Logistic regression analysis was performed for independent factors associated with diabetic retinopathy. RESULTS: The average Lp(a) levels in the study group (68.5 mg/dl) were significantly higher than in the control group (25.1 mg/dl) (P 0.001). The Lp(a) levels were found to increase with increasing severity of diabetic retinopathy. CONCLUSIONS: Serum Lp(a) levels are significantly raised in patients with diabetic retinopathy as compared to those with no retinopathy.